Endocrine Abstracts

Objectives: The most common cause of maternal hyperthyroidism during pregnancy is Graves’ disease (GD). The aim of this study was to investigate the perinatal complications and the risk of thyroid dysfunction at early childhood of mothers with GD during pregnancy.Method: Pregnant women with GD (n=93) and aged-matched randomly selected healthy pregnant women (n=140) were recruited retrospectively. The prenatal and newborn data were coll...

Previously, we have shown that 5α-tetrahydrocorticosterone (5αTHB), the reduced metabolite of corticosterone (B, the main glucocorticoid in rodents), binds to the glucocorticoid receptor, suppresses the HPA axis but has weak in vivo effects on adipose tissue and liver metabolism. Here we have compared the anti-inflammatory effects of B and 5αTHB in three in vitro and in vivo experiments. Cytokine release was measured by cytometric bead array...